胸腺肽与抗生素结合治疗老年急性加重期COPD的临床意义与结局(1)
【摘要】 目的：探討胸腺肽与抗生素结合治疗老年急性加重期慢性阻塞性肺疾病(COPD)的临床意义与结局。方法：本次研究中所纳入的研究对象为2019年1月-2020年1月本院所医治的90例老年急性加重期COPD患者，按照采取的治疗方式将所有研究对象分为对照组(n=45)与观察组(n=45)，对照组采用单纯的抗生素治疗，观察组采用胸腺肽联合抗生素治疗。观察两组的治疗效果、肺功能指标变化及不良反应发生率等相关情况。结果：对照组患者临床治疗有效率为75.56%，明显低于观察组的93.33%(P<0.05)。两组患者治疗前FEV1、FEV1%指标比较差异无统计学意义(P>0.05);治疗后对照组FEV1、FEV1%指标明显低于观察组(P<0.05)。对照组、观察组患者不良反应发生率分别为8.89%、11.10%，两组比较差异无统计学意义(P>0.05)。结论：采用胸腺肽与抗生素结合治疗老年急性加重期COPD患者，疗效确切，能明显缓解患者的临床症状，改善患者的肺功能，可有效地提升临床治疗效果，且不良反应少，安全系数高，值得应用。
【关键词】 胸腺肽 抗生素 老年急性加重期COPD 应用效果
doi：10.14033/j.cnki.cfmr.2020.25.015 文献标识码 B 文章编号 1674-6805(2020)25-00-03
[Abstract] Objective： To explore the clinical significance and outcome of Thymosin combined with antibiotics in the treatment of the elderly with acute exacerbation of COPD. Method： A total of 90 elderly patients with acute exacerbation of COPD treated in our hospital from January 2019 to January 2020 were included in this study， and they were divided into the control group (n=45) and the observation group (n=45) according to the treatment method. The control group was treated with antibiotics alone， and the observation group was treated with Thymosin combined with antibiotics. The treatment effect， changes in lung function indexes and the incidence of adverse reactions in the two groups of patients were observed. Result： The clinical treatment efficiency in the control group was 75.56%， significantly lower than 93.33% in the observation group (P<0.05). Before treatment， the FEV1 and FEV1% indexes of the two groups were not statistically significant (P>0.05). After treatment， the FEV1 and FEV1% indexes of the control group were significantly lower than those of the observation group (P<0.05). The incidence of adverse reactions in the control group and the observation group were 8.89% and 11.10%， respectively， and there was no statistical significance between the two groups (P>0.05). Conclusion： The combination of Thymosin and antibiotics in the treatment of the elderly patients with acute exacerbation of COPD can significantly alleviate the clinical symptoms of patients， improve the patients’ lung function， effectively improve the clinical treatment effect， which has less adverse reactions， high safety factor， which is worth applying and definite curative effect.
[Key words] Thymosin Antibiotics Elderly with acute exacerbation of COPD Application effect
First-author’s address： Second Affiliated Hospital of Suzhou University， Suzhou 215151， China, http://www.100md.com(姜子峰)
【关键词】 胸腺肽 抗生素 老年急性加重期COPD 应用效果
doi：10.14033/j.cnki.cfmr.2020.25.015 文献标识码 B 文章编号 1674-6805(2020)25-00-03
[Abstract] Objective： To explore the clinical significance and outcome of Thymosin combined with antibiotics in the treatment of the elderly with acute exacerbation of COPD. Method： A total of 90 elderly patients with acute exacerbation of COPD treated in our hospital from January 2019 to January 2020 were included in this study， and they were divided into the control group (n=45) and the observation group (n=45) according to the treatment method. The control group was treated with antibiotics alone， and the observation group was treated with Thymosin combined with antibiotics. The treatment effect， changes in lung function indexes and the incidence of adverse reactions in the two groups of patients were observed. Result： The clinical treatment efficiency in the control group was 75.56%， significantly lower than 93.33% in the observation group (P<0.05). Before treatment， the FEV1 and FEV1% indexes of the two groups were not statistically significant (P>0.05). After treatment， the FEV1 and FEV1% indexes of the control group were significantly lower than those of the observation group (P<0.05). The incidence of adverse reactions in the control group and the observation group were 8.89% and 11.10%， respectively， and there was no statistical significance between the two groups (P>0.05). Conclusion： The combination of Thymosin and antibiotics in the treatment of the elderly patients with acute exacerbation of COPD can significantly alleviate the clinical symptoms of patients， improve the patients’ lung function， effectively improve the clinical treatment effect， which has less adverse reactions， high safety factor， which is worth applying and definite curative effect.
[Key words] Thymosin Antibiotics Elderly with acute exacerbation of COPD Application effect
First-author’s address： Second Affiliated Hospital of Suzhou University， Suzhou 215151， China, http://www.100md.com(姜子峰)